Arabidopsis thaliana protein interaction network
Laboratório de Biologia Integrativa e Sistêmica (LaBIS)
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AT5G55310 - ( TOP1BETA (DNA TOPOISOMERASE 1 BETA) DNA topoisomerase type I )

66 Proteins interacs with AT5G55310
LocusMethodFSW Cellular Compartment Classification (C3)Description
AT3G52140Predicted

Affinity Capture-MS

FSW = 0.0117

Unknown

TETRATRICOPEPTIDE REPEAT (TPR)-CONTAINING PROTEIN
AT5G63110

Predicted

Affinity Capture-MS

Affinity Capture-MS

FSW = 0.0800

Unknown

HDA6 (HISTONE DEACETYLASE 6) HISTONE DEACETYLASE
AT4G35830

Predicted

Affinity Capture-MS

FSW = 0.0171

Unknown

ACONITATE HYDRATASE CYTOPLASMIC / CITRATE HYDRO-LYASE / ACONITASE (ACO)
AT5G17770

Predicted

Affinity Capture-MS

FSW = 0.0237

Unknown

ATCBR (ARABIDOPSIS THALIANA NADHCYTOCHROME B5 REDUCTASE 1) CYTOCHROME-B5 REDUCTASE
AT1G11890

Predicted

Phenotypic Suppression

FSW = 0.0742

Unknown

SEC22 TRANSPORTER
AT2G44860

Predicted

Affinity Capture-MS

FSW = 0.0188

Unknown

60S RIBOSOMAL PROTEIN L24 PUTATIVE
AT5G35910

Predicted

Phenotypic Suppression

FSW = 0.1630

Unknown

3-5 EXONUCLEASE DOMAIN-CONTAINING PROTEIN / HELICASE AND RNASE D C-TERMINAL DOMAIN-CONTAINING PROTEIN / HRDC DOMAIN-CONTAINING PROTEIN
AT2G43810

Predicted

Phenotypic Enhancement

FSW = 0.0882

Unknown

SMALL NUCLEAR RIBONUCLEOPROTEIN F PUTATIVE / U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN PUTATIVE / SM PROTEIN F PUTATIVE
AT1G19120

Predicted

Phenotypic Enhancement

FSW = 0.1218

Unknown

SMALL NUCLEAR RIBONUCLEOPROTEIN PUTATIVE / SNRNP PUTATIVE / SM PROTEIN PUTATIVE
AT3G13940

Predicted

Phenotypic Enhancement

interologs mapping

Synthetic Lethality

FSW = 0.0675

Unknown

DNA BINDING / DNA-DIRECTED RNA POLYMERASE
AT4G10710

Predicted

Affinity Capture-MS

Affinity Capture-MS

FSW = 0.0994

Unknown

SPT16 (GLOBAL TRANSCRIPTION FACTOR C)
AT1G48920

Predicted

Affinity Capture-Western

FSW = 0.0151

Unknown

ATNUC-L1 NUCLEIC ACID BINDING / NUCLEOTIDE BINDING
AT1G02840

Predicted

in vitro

in vivo

FSW = 0.0061

Unknown

SR1 RNA BINDING / NUCLEIC ACID BINDING / NUCLEOTIDE BINDING
AT1G05055

Predicted

Phenotypic Enhancement

FSW = 0.0481

Unknown

GTF2H2 (GENERAL TRANSCRIPTION FACTOR IIH 2) GENERAL RNA POLYMERASE II TRANSCRIPTION FACTOR
AT1G07370

Predicted

Phenotypic Suppression

FSW = 0.1567

Unknown

PCNA1 (PROLIFERATING CELLULAR NUCLEAR ANTIGEN) DNA BINDING / DNA POLYMERASE PROCESSIVITY FACTOR/ PROTEIN BINDING
AT4G14300

Predicted

synthetic growth defect

FSW = 0.0224

Unknown

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN PUTATIVE / HNRNP PUTATIVE
AT3G18610

Predicted

in vivo

in vivo

in vitro

in vitro

in vitro

in vivo

FSW = 0.0178

Unknown

ATRANGAP1 (RAN GTPASE-ACTIVATING PROTEIN 1) NUCLEIC ACID BINDING / NUCLEOTIDE BINDING
AT2G06210

Predicted

Phenotypic Enhancement

FSW = 0.0785

Unknown

ELF8 (EARLY FLOWERING 8) BINDING
AT5G41150

Predicted

Phenotypic Enhancement

FSW = 0.0819

Unknown

UVH1 (ULTRAVIOLET HYPERSENSITIVE 1) SINGLE-STRANDED DNA SPECIFIC ENDODEOXYRIBONUCLEASE
AT2G31970

Predicted

Synthetic Lethality

FSW = 0.1222

Unknown

RAD50 ATP BINDING / NUCLEASE/ ZINC ION BINDING
AT3G23890

Predicted

Phenotypic Enhancement

synthetic growth defect

Phenotypic Enhancement

Synthetic Lethality

synthetic growth defect

FSW = 0.0880

Unknown

TOPII (TOPOISOMERASE II) ATP BINDING / DNA BINDING / DNA TOPOISOMERASE (ATP-HYDROLYZING)/ DNA TOPOISOMERASE/ DNA-DEPENDENT ATPASE
AT3G28730

Predicted

Affinity Capture-MS

FSW = 0.0854

Unknown

ATHMG (ARABIDOPSIS THALIANA HIGH MOBILITY GROUP) TRANSCRIPTION FACTOR
AT4G26840

Predicted

Affinity Capture-MS

FSW = 0.0365

Unknown

SUMO1 (SMALL UBIQUITIN-LIKE MODIFIER 1) PROTEIN BINDING / PROTEIN TAG
AT5G54260

Predicted

Synthetic Lethality

Phenotypic Enhancement

FSW = 0.1383

Unknown

MRE11 (MEIOTIC RECOMBINATION 11) ENDONUCLEASE/ EXONUCLEASE/ HYDROLASE/ MANGANESE ION BINDING / PROTEIN SERINE/THREONINE PHOSPHATASE
AT5G37340

Predicted

two hybrid

FSW = 0.0257

Unknown

ZINC FINGER (ZPR1-TYPE) FAMILY PROTEIN
AT1G09020

Predicted

Phenotypic Enhancement

FSW = 0.0135

Unknown

SNF4 (HOMOLOG OF YEAST SUCROSE NONFERMENTING 4) PROTEIN KINASE ACTIVATOR
AT1G10930

Predicted

synthetic growth defect

synthetic growth defect

Synthetic Lethality

synthetic growth defect

Synthetic Lethality

Synthetic Lethality

synthetic growth defect

Phenotypic Enhancement

FSW = 0.1101

Unknown

RECQ4A ATP BINDING / ATP-DEPENDENT HELICASE/ HELICASE/ NUCLEIC ACID BINDING
AT1G18090

Predicted

Synthetic Lethality

FSW = 0.1320

Unknown

EXONUCLEASE PUTATIVE
AT1G24706

Predicted

Phenotypic Enhancement

FSW = 0.0046

Unknown

UNKNOWN PROTEIN
AT1G49520

Predicted

two hybrid

two hybrid

FSW = 0.0105

Unknown

SWIB COMPLEX BAF60B DOMAIN-CONTAINING PROTEIN
AT1G66740

Predicted

Synthetic Lethality

FSW = 0.0943

Unknown

SGA2
AT1G79730

Predicted

Phenotypic Enhancement

FSW = 0.0618

Unknown

ELF7 (EARLY FLOWERING 7)
AT2G27600

Predicted

Synthetic Rescue

FSW = 0.0192

Unknown

SKD1 (SUPPRESSOR OF K+ TRANSPORT GROWTH DEFECT1) ATP BINDING / NUCLEOSIDE-TRIPHOSPHATASE/ NUCLEOTIDE BINDING
AT2G34770

Predicted

Phenotypic Enhancement

FSW = 0.0153

Unknown

FAH1 (FATTY ACID HYDROXYLASE 1) CATALYTIC/ FATTY ACID ALPHA-HYDROXYLASE
AT3G10070

Predicted

Phenotypic Suppression

FSW = 0.0210

Unknown

TAF12 (TBP-ASSOCIATED FACTOR 12) DNA BINDING / TRANSCRIPTION INITIATION FACTOR
AT3G18520

Predicted

Phenotypic Suppression

FSW = 0.0699

Unknown

HDA15 HISTONE DEACETYLASE
AT3G20630

Predicted

Affinity Capture-MS

FSW = 0.0479

Unknown

UBP14 (UBIQUITIN-SPECIFIC PROTEASE 14) UBIQUITIN-SPECIFIC PROTEASE
AT3G22480

Predicted

Phenotypic Suppression

FSW = 0.0930

Unknown

PREFOLDIN-RELATED KE2 FAMILY PROTEIN
AT3G46960Predicted

Phenotypic Suppression

FSW = 0.0448

Unknown

ATP BINDING / ATP-DEPENDENT HELICASE/ HELICASE/ HYDROLASE ACTING ON ACID ANHYDRIDES IN PHOSPHORUS-CONTAINING ANHYDRIDES / NUCLEIC ACID BINDING
AT3G54380

Predicted

Phenotypic Enhancement

FSW = 0.0896

Unknown

SAC3/GANP FAMILY PROTEIN
AT4G22140

Predicted

Phenotypic Enhancement

FSW = 0.0848

Unknown

DNA BINDING / PROTEIN BINDING / ZINC ION BINDING
AT4G30870

Predicted

Phenotypic Enhancement

FSW = 0.0918

Unknown

MUS81 (MMS AND UV SENSITIVE 81) ENDONUCLEASE/ NUCLEIC ACID BINDING
AT4G33100

Predicted

Phenotypic Suppression

FSW = 0.0981

Unknown

FUNCTIONS IN MOLECULAR_FUNCTION UNKNOWN INVOLVED IN BIOLOGICAL_PROCESS UNKNOWN LOCATED IN CELLULAR_COMPONENT UNKNOWN EXPRESSED IN 23 PLANT STRUCTURES EXPRESSED DURING 15 GROWTH STAGES CONTAINS INTERPRO DOMAIN/S MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY FAMILY 35/APOPTOSIS (INTERPROIPR007918) HAS 160 BLAST HITS TO 160 PROTEINS IN 70 SPECIES ARCHAE - 0 BACTERIA - 0 METAZOA - 95 FUNGI - 46 PLANTS - 13 VIRUSES - 0 OTHER EUKARYOTES - 6 (SOURCE NCBI BLINK)
AT5G10260

Predicted

Phenotypic Enhancement

FSW = 0.0883

Unknown

ATRABH1E (ARABIDOPSIS RAB GTPASE HOMOLOG H1E) GTP BINDING
AT5G10390Predicted

Phenotypic Enhancement

FSW = 0.0634

Unknown

HISTONE H3
AT5G23290

Predicted

Phenotypic Suppression

FSW = 0.0188

Unknown

PDF5 (PREFOLDIN 5) UNFOLDED PROTEIN BINDING
AT5G38890

Predicted

Phenotypic Suppression

FSW = 0.0173

Unknown

EXORIBONUCLEASE-RELATED
AT5G53770

Predicted

Phenotypic Enhancement

Synthetic Lethality

Phenotypic Enhancement

Synthetic Lethality

FSW = 0.0940

Unknown

NUCLEOTIDYLTRANSFERASE FAMILY PROTEIN
AT1G07430

Predicted

Dosage Growth Defect

FSW = 0.0397

Unknown

PROTEIN PHOSPHATASE 2C PUTATIVE / PP2C PUTATIVE
AT1G50490

Predicted

Phenotypic Enhancement

FSW = 0.0155

Unknown

UBC20 (UBIQUITIN-CONJUGATING ENZYME 20) UBIQUITIN-PROTEIN LIGASE
AT1G54390

Predicted

Phenotypic Enhancement

FSW = 0.0378

Unknown

PHD FINGER PROTEIN-RELATED
AT2G13680

Predicted

Synthetic Lethality

Synthetic Lethality

FSW = 0.0352

Unknown

CALS5 (CALLOSE SYNTHASE 5) 13-BETA-GLUCAN SYNTHASE
AT3G06910

Predicted

Synthetic Rescue

FSW = 0.0828

Unknown

ULP1A (UB-LIKE PROTEASE 1A) SUMO-SPECIFIC PROTEASE/ CYSTEINE-TYPE PEPTIDASE
AT3G25100

Predicted

Synthetic Lethality

Synthetic Lethality

FSW = 0.1168

Unknown

CDC45 (CELL DIVISION CYCLE 45)
AT3G42660

Predicted

Phenotypic Suppression

FSW = 0.1657

Unknown

NUCLEOTIDE BINDING
AT3G57870

Predicted

Synthetic Lethality

FSW = 0.0253

Unknown

SCE1 (SUMO CONJUGATION ENZYME 1) SUMO LIGASE
AT3G60240

Predicted

Affinity Capture-MS

FSW = 0.0126

Unknown

EIF4G (EUKARYOTIC TRANSLATION INITIATION FACTOR 4G) TRANSLATION INITIATION FACTOR
AT4G33620Predicted

Phenotypic Enhancement

FSW = 0.0986

Unknown

ULP1 PROTEASE FAMILY PROTEIN
AT5G26680

Predicted

Synthetic Rescue

FSW = 0.1163

Unknown

ENDONUCLEASE PUTATIVE
AT5G43500

Predicted

Phenotypic Suppression

FSW = 0.1322

Unknown

ATARP9 (ACTIN-RELATED PROTEIN 9) DNA BINDING / PROTEIN BINDING
AT5G49010

Predicted

Affinity Capture-MS

FSW = 0.0616

Unknown

SLD5 (SYNTHETIC LETHALITY WITH DPB11-1 5)
AT5G61770

Predicted

Phenotypic Suppression

FSW = 0.0308

Unknown

PPAN (PETER PAN-LIKE PROTEIN)
AT5G63920

Predicted

Synthetic Lethality

Phenotypic Enhancement

FSW = 0.1591

Unknown

DNA TOPOISOMERASE III ALPHA PUTATIVE
AT5G66100

Predicted

Phenotypic Suppression

FSW = 0.1030

Unknown

LA DOMAIN-CONTAINING PROTEIN
AT3G05250

Predicted

in vitro

in vivo

two hybrid

FSW = 0.0580

Unknown

ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN
AT5G55300

Predicted

Enriched domain pair

Phylogenetic profile method

Co-expression

FSW = 0.4246

Unknown

TOP1ALPHA (DNA TOPOISOMERASE I ALPHA) DNA TOPOISOMERASE TYPE I

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Fasta sequences:

Proteins

DNA

Quick help

Experimental: This means that the indicated PPI was experimentally demonstrated using Arabidopsis thaliana proteins as model of study. The experiment indicated links to the publication of which this interaction was annotated from
Predicted: The indicated PPI was proposed based on ortholgs studies. The experiment indicated links to the publication of the orthologous PPI was annotated from

FSW

FSW is the Functional Similarity Weight. It represents the proportion of interaction partners that two proteins have in common

Learn more - FSWeight top ranked cut offs

C3

Class A: The PPI is a direct evidence (experimental), the subcellular location was experimentally demonstrated and both, target and source, were indicated as expressed in same cellular compartment
Class B: The PPI is a direct evidence (experimental), the subcellular location was experimentally demonstrated but both, target and source, were indicated as expressed in different cellular compartment
Class C: Same as Class A but the PPI is predicted
Class D: Same as Class A but subcellular location was predicted. P(exp|pred) indicates the probability of this particular predicted location be experimentally demonstrated given all data available on AtPINDB
Unknown: There is no available data to calculate the C3 or the data does not fit onto any class previously described

PEP

PEP is the posterior probability of this particular PPI be experimentally demonstrated once it was predicted. For this release p = 0.0030. If they share same cell compartment p = 0.0029

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How to cite

If you find AtPIN interesting and want to use it in your work please cite us

AtPIN: Arabidopsis thaliana Protein Interaction Network
Marcelo M Brandao, Luiza L Dantas and Marcio C Silva-Filho
BMC Bioinformatics 2009, 10:454

DOI:1471-2105/10/454