Arabidopsis thaliana protein interaction network
Laboratório de Biologia Integrativa e Sistêmica (LaBIS)
Laboratório de Biologia Integrativa e Sistêmica (LaBIS)
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AT4G08500 - ( MEKK1 (MAP KINASE KINASE KINASE 1) DNA binding / MAP kinase kinase kinase/ kinase/ kinase binding / protein binding )
64 Proteins interacs with AT4G08500| Locus | Method | FSW  | Cellular Compartment Classification (C3) | Description |
|---|---|---|---|---|
AT4G01370
   | Experimentaltwo hybrid | FSW = 0.0402
| Unknown | ATMPK4 (ARABIDOPSIS THALIANA MAP KINASE 4) MAP KINASE/ KINASE |
| AT5G57090
| Experimental | FSW = 0.0159
| Unknown | EIR1 (ETHYLENE INSENSITIVE ROOT 1) AUXIN EFFLUX TRANSMEMBRANE TRANSPORTER/ AUXINHYDROGEN SYMPORTER/ TRANSPORTER |
| AT4G29810
| Experimentalprotein complementation assaysplit-reporter assay | FSW = 0.0390
| Unknown | ATMKK2 (ARABIDOPSIS THALIANA MAP KINASE KINASE 2) MAP KINASE KINASE/ KINASE |
| AT4G23810
| Experimentalprotein kinase assayprotein complementation assaytwo hybrid | FSW = 0.0171
| Unknown | WRKY53 DNA BINDING / PROTEIN BINDING / TRANSCRIPTION ACTIVATOR/ TRANSCRIPTION FACTOR |
| AT1G20140
| Experimentalone hybrid | FSW = 0.0037
| Unknown | ASK4 (ARABIDOPSIS SKP1-LIKE 4) PROTEIN BINDING / UBIQUITIN-PROTEIN LIGASE |
| AT4G26070
| Experimentaltwo hybridtwo hybridcoimmunoprecipitationtwo hybridprotein complementation assaycoimmunoprecipitationsplit-reporter assay | FSW = 0.0320
| Unknown | MEK1 (MAP KINASE/ ERK KINASE 1) MAP KINASE KINASE/ KINASE/ PROTEIN BINDING |
| AT5G06140
| Experimentalfar western blotting | FSW = 0.0183
| Unknown | SNX1 (SORTING NEXIN 1) PHOSPHOINOSITIDE BINDING / PROTEIN BINDING |
| AT5G35750
| Experimental | FSW = 0.0046
| Unknown | AHK2 (ARABIDOPSIS HISTIDINE KINASE 2) CYTOKININ RECEPTOR/ OSMOSENSOR/ PROTEIN HISTIDINE KINASE |
| AT5G63400
| Predictedbiochemical | FSW = 0.0075
| Unknown | ADK1 (ADENYLATE KINASE 1) ATP BINDING / ADENYLATE KINASE/ NUCLEOBASE NUCLEOSIDE NUCLEOTIDE KINASE/ NUCLEOTIDE KINASE/ PHOSPHOTRANSFERASE PHOSPHATE GROUP AS ACCEPTOR |
| AT5G14120
| Predictedbiochemical | FSW = 0.0304
| Unknown | NODULIN FAMILY PROTEIN |
| AT4G11860
| Predictedbiochemical | FSW = 0.0146
| Unknown | FUNCTIONS IN MOLECULAR_FUNCTION UNKNOWN INVOLVED IN BIOLOGICAL_PROCESS UNKNOWN LOCATED IN CYTOSOL NUCLEUS PLASMA MEMBRANE EXPRESSED IN 25 PLANT STRUCTURES EXPRESSED DURING 14 GROWTH STAGES CONTAINS INTERPRO DOMAIN/S PROTEIN OF UNKNOWN FUNCTION DUF544 (INTERPROIPR007518) UBIQUITIN INTERACTING MOTIF (INTERPROIPR003903) BEST ARABIDOPSIS THALIANA PROTEIN MATCH IS UNKNOWN PROTEIN (TAIRAT4G229601) HAS 761 BLAST HITS TO 466 PROTEINS IN 133 SPECIES ARCHAE - 0 BACTERIA - 44 METAZOA - 311 FUNGI - 246 PLANTS - 57 VIRUSES - 0 OTHER EUKARYOTES - 103 (SOURCE NCBI BLINK) |
| AT5G46800
| Predictedbiochemical | FSW = 0.0142
| Unknown | BOU (A BOUT DE SOUFFLE) BINDING / TRANSPORTER |
| AT5G63840
| PredictedSynthetic Lethality | FSW = 0.0423
| Unknown | RSW3 (RADIAL SWELLING 3) GLUCOSIDASE/ HYDROLASE HYDROLYZING O-GLYCOSYL COMPOUNDS |
| AT1G51730
| Predictedbiochemical | FSW = 0.0529
| Unknown | RWD DOMAIN-CONTAINING PROTEIN |
| AT1G49340
| PredictedSynthetic Lethality | FSW = 0.0386
| Unknown | ATPI4K ALPHA 1-PHOSPHATIDYLINOSITOL 4-KINASE/ INOSITOL OR PHOSPHATIDYLINOSITOL KINASE |
| AT3G11964 | Predictedbiochemical | FSW = 0.0235
| Unknown | RNA BINDING |
| AT5G52640
| PredictedSynthetic Lethality | FSW = 0.0302
| Unknown | ATHSP901 (HEAT SHOCK PROTEIN 901) ATP BINDING / UNFOLDED PROTEIN BINDING |
| AT4G25630
| PredictedAffinity Capture-MS | FSW = 0.0233
| Unknown | FIB2 (FIBRILLARIN 2) SNORNA BINDING |
| AT4G10710
| Predictedbiochemical | FSW = 0.0032
| Unknown | SPT16 (GLOBAL TRANSCRIPTION FACTOR C) |
| AT3G25940
| Predictedbiochemical | FSW = 0.0212
| Unknown | TRANSCRIPTION FACTOR S-II (TFIIS) DOMAIN-CONTAINING PROTEIN |
| AT3G12860
| PredictedAffinity Capture-MS | FSW = 0.0515
| Unknown | NUCLEOLAR PROTEIN NOP56 PUTATIVE |
| AT1G14610
| Predictedbiochemical | FSW = 0.0184
| Unknown | TWN2 (TWIN 2) ATP BINDING / AMINOACYL-TRNA LIGASE/ NUCLEOTIDE BINDING / VALINE-TRNA LIGASE |
| AT5G02050
| Predictedbiochemical | FSW = 0.0495
| Unknown | MITOCHONDRIAL GLYCOPROTEIN FAMILY PROTEIN / MAM33 FAMILY PROTEIN |
| AT5G26710
| Predictedbiochemical | FSW = 0.0050
| Unknown | GLUTAMATE-TRNA LIGASE PUTATIVE / GLUTAMYL-TRNA SYNTHETASE PUTATUVE / GLURS PUTATIVE |
| AT1G67490
| PredictedSynthetic Lethality | FSW = 0.0716
| Unknown | GCS1 (GLUCOSIDASE 1) ALPHA-GLUCOSIDASE |
| AT2G44660
| PredictedSynthetic Lethality | FSW = 0.0397
| Unknown | TRANSFERASE TRANSFERRING GLYCOSYL GROUPS / TRANSFERASE TRANSFERRING HEXOSYL GROUPS |
| AT2G31970
| PredictedSynthetic Lethality | FSW = 0.0232
| Unknown | RAD50 ATP BINDING / NUCLEASE/ ZINC ION BINDING |
| AT2G31300
| PredictedSynthetic Lethality | FSW = 0.0736
| Unknown | ARPC1B (ACTIN-RELATED PROTEIN C1B) ACTIN BINDING / NUCLEOTIDE BINDING |
| AT1G61700
| Predictedbiochemical | FSW = 0.0160
| Unknown | DNA-DIRECTED RNA POLYMERASE II PUTATIVE (RPB10) |
| AT1G02120
| PredictedAffinity Capture-MS | FSW = 0.0588
| Unknown | VAD1 (VASCULAR ASSOCIATED DEATH1) |
| AT1G06720
| Predictedbiochemical | FSW = 0.0182
| Unknown | INVOLVED IN RIBOSOME BIOGENESIS LOCATED IN NUCLEUS EXPRESSED IN 21 PLANT STRUCTURES EXPRESSED DURING 13 GROWTH STAGES CONTAINS INTERPRO DOMAIN/S AARP2CN (INTERPROIPR012948) PROTEIN OF UNKNOWN FUNCTION DUF663 (INTERPROIPR007034) BEST ARABIDOPSIS THALIANA PROTEIN MATCH IS UNKNOWN PROTEIN (TAIRAT1G424401) HAS 7944 BLAST HITS TO 5342 PROTEINS IN 373 SPECIES ARCHAE - 33 BACTERIA - 667 METAZOA - 2609 FUNGI - 1045 PLANTS - 414 VIRUSES - 80 OTHER EUKARYOTES - 3096 (SOURCE NCBI BLINK) |
| AT2G22400
| Predictedbiochemical | FSW = 0.1131
| Unknown | NOL1/NOP2/SUN FAMILY PROTEIN |
| AT2G29210
| Predictedbiochemical | FSW = 0.0621
| Unknown | SPLICING FACTOR PWI DOMAIN-CONTAINING PROTEIN |
| AT2G39840
| PredictedPhenotypic Enhancement | FSW = 0.0141
| Unknown | TOPP4 PROTEIN SERINE/THREONINE PHOSPHATASE |
| AT3G18430
| PredictedSynthetic Lethality | FSW = 0.0182
| Unknown | CALCIUM-BINDING EF HAND FAMILY PROTEIN |
| AT3G23270
| Predictedbiochemical | FSW = 0.0571
| Unknown | REGULATOR OF CHROMOSOME CONDENSATION (RCC1) FAMILY PROTEIN |
| AT3G25230
| Predictedbiochemical | FSW = 0.0376
| Unknown | ROF1 (ROTAMASE FKBP 1) FK506 BINDING / CALMODULIN BINDING / PEPTIDYL-PROLYL CIS-TRANS ISOMERASE |
| AT1G04160
| PredictedSynthetic Lethality | FSW = 0.0468
| Unknown | XIB (MYOSIN XI B) MOTOR |
| AT1G08780
| PredictedSynthetic Lethality | FSW = 0.0594
| Unknown | AIP3 (ABI3-INTERACTING PROTEIN 3) UNFOLDED PROTEIN BINDING |
| AT1G20575
| PredictedSynthetic Rescue | FSW = 0.0251
| Unknown | DOLICHYL-PHOSPHATE BETA-D-MANNOSYLTRANSFERASE PUTATIVE / DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE PUTATIVE / MANNOSE-P-DOLICHOL SYNTHASE PUTATIVE |
| AT1G26450
| PredictedSynthetic LethalitySynthetic LethalitySynthetic Lethality | FSW = 0.0935
| Unknown | BETA-13-GLUCANASE-RELATED |
| AT1G29990
| PredictedSynthetic Lethality | FSW = 0.0321
| Unknown | PDF6 (PREFOLDIN 6) UNFOLDED PROTEIN BINDING |
| AT1G50030
| Predictedinterologs mapping | FSW = 0.0755
| Unknown | TOR (TARGET OF RAPAMYCIN) 1-PHOSPHATIDYLINOSITOL-3-KINASE/ PROTEIN BINDING |
| AT1G54140
| PredictedSynthetic Lethality | FSW = 0.0076
| Unknown | TAFII21 (TATA BINDING PROTEIN ASSOCIATED FACTOR 21KDA SUBUNIT) DNA BINDING / TRANSCRIPTION INITIATION FACTOR |
| AT1G73570
| PredictedSynthetic LethalitySynthetic Lethality | FSW = 0.0698
| Unknown | SUPPRESSOR OF LIN-12-LIKE PROTEIN-RELATED / SEL-1 PROTEIN-RELATED |
| AT1G80410
| Predictedsynthetic growth defect | FSW = 0.0370
| Unknown | EMB2753 (EMBRYO DEFECTIVE 2753) BINDING |
| AT2G02760
| Predictedsynthetic growth defect | FSW = 0.0092
| Unknown | ATUBC2 (UBIQUITING-CONJUGATING ENZYME 2) UBIQUITIN-PROTEIN LIGASE |
| AT2G22530
| PredictedSynthetic Lethality | FSW = 0.0755
| Unknown | CATALYTIC/ TRANSFERASE |
| AT3G11910
| PredictedAffinity Capture-MS | FSW = 0.0298
| Unknown | UBP13 (UBIQUITIN-SPECIFIC PROTEASE 13) UBIQUITIN THIOLESTERASE/ UBIQUITIN-SPECIFIC PROTEASE |
| AT3G27000
| PredictedSynthetic Lethality | FSW = 0.0305
| Unknown | ARP2 (ACTIN RELATED PROTEIN 2) PROTEIN BINDING / STRUCTURAL CONSTITUENT OF CYTOSKELETON |
| AT5G13780
| Predictedsynthetic growth defect | FSW = 0.0398
| Unknown | GCN5-RELATED N-ACETYLTRANSFERASE PUTATIVE |
| AT5G23290
| PredictedSynthetic Lethality | FSW = 0.0247
| Unknown | PDF5 (PREFOLDIN 5) UNFOLDED PROTEIN BINDING |
| AT5G40440
| PredictedAffinity Capture-MStwo hybrid | FSW = 0.0386
| Unknown | ATMKK3 (ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3) MAP KINASE KINASE |
| AT4G16630
| Predictedbiochemical | FSW = 0.0270
| Unknown | DEAD/DEAH BOX HELICASE PUTATIVE (RH28) |
| AT4G17890
| Predictedbiochemical | FSW = 0.0664
| Unknown | AGD8 (ARF-GAP DOMAIN 8) ARF GTPASE ACTIVATOR/ DNA BINDING / ZINC ION BINDING |
| AT4G22540
| Predictedbiochemical | FSW = 0.0140
| Unknown | ORP2A (OSBP(OXYSTEROL BINDING PROTEIN)-RELATED PROTEIN 2A) OXYSTEROL BINDING / PHOSPHOINOSITIDE BINDING |
| AT4G27650
| Predictedbiochemical | FSW = 0.0335
| Unknown | PEL1 (PELOTA) TRANSLATION RELEASE FACTOR |
| AT4G29330
| Predictedbiochemical | FSW = 0.0148
| Unknown | DER1 (DERLIN-1) |
| AT5G08415
| Predictedbiochemical | FSW = 0.0149
| Unknown | LIPOIC ACID SYNTHASE FAMILY PROTEIN |
| AT5G20600
| Predictedbiochemical | FSW = 0.0160
| Unknown | FUNCTIONS IN MOLECULAR_FUNCTION UNKNOWN INVOLVED IN RRNA PROCESSING LOCATED IN PRERIBOSOME SMALL SUBUNIT PRECURSOR EXPRESSED IN 22 PLANT STRUCTURES EXPRESSED DURING 13 GROWTH STAGES CONTAINS INTERPRO DOMAIN/S NUCLEOLAR NOP52 (INTERPROIPR010301) HAS 444 BLAST HITS TO 431 PROTEINS IN 151 SPECIES ARCHAE - 0 BACTERIA - 10 METAZOA - 196 FUNGI - 114 PLANTS - 27 VIRUSES - 0 OTHER EUKARYOTES - 97 (SOURCE NCBI BLINK) |
| AT5G26180
| Predictedbiochemical | FSW = 0.0312
| Unknown | NOL1/NOP2/SUN FAMILY PROTEIN |
| AT5G27490
| PredictedAffinity Capture-MS | FSW = 0.0335
| Unknown | INTEGRAL MEMBRANE YIP1 FAMILY PROTEIN |
| AT5G35980
| Predictedbiochemical | FSW = 0.0332
| Unknown | PROTEIN KINASE FAMILY PROTEIN |
| AT5G67220
| Predictedbiochemical | FSW = 0.0311
| Unknown | NITROGEN REGULATION FAMILY PROTEIN |
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Experimental: This means that the indicated PPI was experimentally demonstrated using Arabidopsis thaliana proteins as model of study. The experiment indicated links to the publication of which this interaction was annotated from
Predicted: The indicated PPI was proposed based on ortholgs studies. The experiment indicated links to the publication of the orthologous PPI was annotated from
FSW
FSW is the Functional Similarity Weight. It represents the proportion of interaction partners that two proteins have in commonLearn more - FSWeight top ranked cut offs
C3
Class A: The PPI is a direct evidence (experimental), the subcellular location was experimentally demonstrated and both, target and source, were indicated as expressed in same cellular compartment
Class B: The PPI is a direct evidence (experimental), the subcellular location was experimentally demonstrated but both, target and source, were indicated as expressed in different cellular compartment
Class C: Same as Class A but the PPI is predicted
Class D: Same as Class A but subcellular location was predicted. P(exp|pred) indicates the probability of this particular predicted location be experimentally demonstrated given all data available on AtPINDB
Unknown: There is no available data to calculate the C3 or the data does not fit onto any class previously described
PEP
PEP is the posterior probability of this particular PPI be experimentally demonstrated once it was predicted. For this release p = 0.0030. If they share same cell compartment p = 0.0029Learn more
How to cite
If you find AtPIN interesting and want to use it in your work please cite usAtPIN: Arabidopsis thaliana Protein Interaction Network
Marcelo M Brandao, Luiza L Dantas and Marcio C Silva-Filho
BMC Bioinformatics 2009, 10:454DOI:1471-2105/10/454
Marcelo M Brandao, Luiza L Dantas and Marcio C Silva-Filho
BMC Bioinformatics 2009, 10:454DOI:1471-2105/10/454
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