Arabidopsis thaliana protein interaction network
Laboratório de Biologia Integrativa e Sistêmica (LaBIS)
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AT5G02490 - ( heat shock cognate 70 kDa protein 2 (HSC70-2) (HSP70-2) )

93 Proteins interacs with AT5G02490
LocusMethodFSW Cellular Compartment Classification (C3)Description
AT1G78300

Experimental

FSW = 0.0011

Class A:

plasma membrane

Class B:

vacuole

peroxisome

nucleus

cytosol

cytoskeleton

Class D:

cytosol (p = 0.67)

 GRF2 (GENERAL REGULATORY FACTOR 2) PROTEIN BINDING / PROTEIN PHOSPHORYLATED AMINO ACID BINDING
AT4G11260

Experimental

interaction detection method

pull down

FSW = 0.0459

Unknown

 SGT1B PROTEIN BINDING
AT5G15090

Predicted

Synthetic Lethality

FSW = 0.0185

Class C:

plasma membrane

 VDAC3 (VOLTAGE DEPENDENT ANION CHANNEL 3) VOLTAGE-GATED ANION CHANNEL
AT5G02500

Predicted

Gene neighbors method

Phylogenetic profile method

Co-expression

FSW = 0.1089

Class C:

plasma membrane

 HSC70-1 (HEAT SHOCK COGNATE PROTEIN 70-1) ATP BINDING
AT5G42080

Predicted

Phenotypic Enhancement

FSW = 0.0088

Class C:

plasma membrane

 ADL1 (ARABIDOPSIS DYNAMIN-LIKE PROTEIN) GTP BINDING / GTPASE/ PROTEIN BINDING
AT3G09440

Predicted

Phylogenetic profile method

Co-expression

FSW = 0.0502

Class C:

plasma membrane

 HEAT SHOCK COGNATE 70 KDA PROTEIN 3 (HSC70-3) (HSP70-3)
AT3G12580

Predicted

Phylogenetic profile method

Co-expression

FSW = 0.1236

Class C:

plasma membrane

 HSP70 (HEAT SHOCK PROTEIN 70) ATP BINDING
AT5G56000

Predicted

in vivo

Affinity Capture-MS

FSW = 0.0335

Class C:

plasma membrane

 HEAT SHOCK PROTEIN 81-4 (HSP81-4)
AT4G36750

Predicted

Affinity Capture-MS

Affinity Capture-MS

Affinity Capture-MS

Affinity Capture-MS

two hybrid

FSW = 0.0781

Class C:

plasma membrane

 QUINONE REDUCTASE FAMILY PROTEIN
AT1G16030

Predicted

Phylogenetic profile method

Co-expression

FSW = 0.0329

Class C:

plasma membrane

 HSP70B (HEAT SHOCK PROTEIN 70B) ATP BINDING
AT1G08450

Predicted

two hybrid

FSW = 0.0111

Class C:

plasma membrane

 CRT3 (CALRETICULIN 3) CALCIUM ION BINDING / UNFOLDED PROTEIN BINDING
AT5G03160

Predicted

two hybrid

FSW = 0.0378

Class C:

plasma membrane

 ATP58IPK (ARABIDOPSIS HOMOLOG OF MAMALLIAN P58IPK) BINDING / HEAT SHOCK PROTEIN BINDING
AT1G79920

Predicted

in vivo

Affinity Capture-MS

FSW = 0.1098

Class C:

plasma membrane

 ATP BINDING
AT5G19990

Predicted

Affinity Capture-MS

FSW = 0.0057

Class C:

plasma membrane

 RPT6A (REGULATORY PARTICLE TRIPLE-A ATPASE 6A) ATPASE
AT5G47100

Predicted

two hybrid

Synthetic Lethality

Synthetic Rescue

FSW = 0.0079

Class C:

plasma membrane

 CBL9 CALCIUM ION BINDING
AT5G26340

Predicted

two hybrid

FSW = 0.0291

Class C:

plasma membrane

 MSS1 CARBOHYDRATE TRANSMEMBRANE TRANSPORTER/ HEXOSEHYDROGEN SYMPORTER/ HIGH-AFFINITY HYDROGENGLUCOSE SYMPORTER/ SUGARHYDROGEN SYMPORTER
AT2G30970

Predicted

in vivo

in vitro

Affinity Capture-MS

FSW = 0.0348

Unknown

 ASP1 (ASPARTATE AMINOTRANSFERASE 1) L-ASPARTATE2-OXOGLUTARATE AMINOTRANSFERASE
AT1G31780

Predicted

two hybrid

FSW = 0.0167

Unknown

 FUNCTIONS IN MOLECULAR_FUNCTION UNKNOWN INVOLVED IN BIOLOGICAL_PROCESS UNKNOWN LOCATED IN CELLULAR_COMPONENT UNKNOWN EXPRESSED IN 24 PLANT STRUCTURES EXPRESSED DURING 15 GROWTH STAGES CONTAINS INTERPRO DOMAIN/S CONSERVED OLIGOMERIC COMPLEX COG6 (INTERPROIPR010490) HAS 281 BLAST HITS TO 279 PROTEINS IN 131 SPECIES ARCHAE - 0 BACTERIA - 2 METAZOA - 132 FUNGI - 106 PLANTS - 21 VIRUSES - 0 OTHER EUKARYOTES - 20 (SOURCE NCBI BLINK)
AT5G23670

Predicted

two hybrid

FSW = 0.0120

Unknown

 LCB2 PROTEIN BINDING / SERINE C-PALMITOYLTRANSFERASE
AT3G07180

Predicted

two hybrid

FSW = 0.0284

Unknown

 GPI TRANSAMIDASE COMPONENT PIG-S-RELATED
AT3G62870

Predicted

synthetic growth defect

FSW = 0.0202

Unknown

 60S RIBOSOMAL PROTEIN L7A (RPL7AB)
AT5G10350

Predicted

Affinity Capture-MS

FSW = 0.0086

Unknown

 POLYADENYLATE-BINDING PROTEIN FAMILY PROTEIN / PABP FAMILY PROTEIN
AT3G19980

Predicted

Affinity Capture-MS

FSW = 0.0121

Unknown

 ATFYPP3 (FLOWER-SPECIFIC PHYTOCHROME-ASSOCIATED PROTEIN PHOSPHATASE 3) PROTEIN BINDING / PROTEIN SERINE/THREONINE KINASE/ PROTEIN SERINE/THREONINE PHOSPHATASE
AT3G62030

Predicted

interologs mapping

FSW = 0.0316

Unknown

 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CHLOROPLAST / CYCLOPHILIN / ROTAMASE / CYCLOSPORIN A-BINDING PROTEIN (ROC4)
AT4G08870

Predicted

two hybrid

FSW = 0.0124

Unknown

 ARGINASE PUTATIVE
AT2G37020

Predicted

two hybrid

FSW = 0.0128

Unknown

 DNA BINDING / SEQUENCE-SPECIFIC DNA BINDING
AT1G56410

Predicted

Phylogenetic profile method

Co-expression

FSW = 0.0720

Unknown

 ERD2 (EARLY-RESPONSIVE TO DEHYDRATION 2) ATP BINDING
AT5G04740

Predicted

in vivo

Affinity Capture-MS

FSW = 0.0112

Unknown

 ACT DOMAIN-CONTAINING PROTEIN
AT4G23430

Predicted

Affinity Capture-MS

FSW = 0.0075

Unknown

 SHORT-CHAIN DEHYDROGENASE/REDUCTASE (SDR) FAMILY PROTEIN
AT5G63110

Predicted

Reconstituted Complex

Affinity Capture-MS

FSW = 0.0090

Unknown

 HDA6 (HISTONE DEACETYLASE 6) HISTONE DEACETYLASE
AT1G66750

Predicted

two hybrid

FSW = 0.0043

Unknown

 CAK4 (CDK-ACTIVATING KINASE 4) KINASE/ PROTEIN BINDING / PROTEIN SERINE/THREONINE KINASE
AT2G43810

Predicted

Affinity Capture-MS

FSW = 0.0133

Unknown

 SMALL NUCLEAR RIBONUCLEOPROTEIN F PUTATIVE / U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN PUTATIVE / SM PROTEIN F PUTATIVE
AT2G03870

Predicted

Affinity Capture-MS

FSW = 0.0211

Unknown

 SMALL NUCLEAR RIBONUCLEOPROTEIN PUTATIVE / SNRNP PUTATIVE / SM PROTEIN PUTATIVE
AT5G43840

Predicted

two hybrid

FSW = 0.0505

Unknown

 AT-HSFA6A DNA BINDING / TRANSCRIPTION FACTOR
AT4G32420

Predicted

in vitro

Reconstituted Complex

FSW = 0.0363

Unknown

 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CYCLOPHILIN-TYPE FAMILY PROTEIN
AT3G19840

Predicted

Affinity Capture-MS

FSW = 0.0198

Unknown

 FF DOMAIN-CONTAINING PROTEIN / WW DOMAIN-CONTAINING PROTEIN
AT5G16820

Predicted

in vivo

in vitro

Affinity Capture-MS

FSW = 0.0617

Unknown

 HSF3 (HEAT SHOCK FACTOR 3) DNA BINDING / TRANSCRIPTION FACTOR
AT4G25210

Predicted

interologs mapping

FSW = 0.0720

Unknown

 TRANSCRIPTION REGULATOR
AT5G48970

Predicted

two hybrid

FSW = 0.0079

Unknown

 MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN
AT5G48030

Predicted

in vivo

Affinity Capture-MS

FSW = 0.0224

Unknown

 GFA2 (GAMETOPHYTIC FACTOR 2) HEAT SHOCK PROTEIN BINDING / UNFOLDED PROTEIN BINDING
AT2G17270

Predicted

Phenotypic Enhancement

FSW = 0.0086

Unknown

 MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN
AT4G10040

Predicted

Affinity Capture-MS

in vivo

in vitro

FSW = 0.0155

Unknown

 CYTC-2 (CYTOCHROME C-2) ELECTRON CARRIER/ HEME BINDING / IRON ION BINDING
AT2G13650

Predicted

Affinity Capture-MS

FSW = 0.0267

Unknown

 GONST1 (GOLGI NUCLEOTIDE SUGAR TRANSPORTER 1) GDP-MANNOSE TRANSMEMBRANE TRANSPORTER/ NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER
AT5G02730

Predicted

Affinity Capture-MS

FSW = 0.0110

Unknown

 ALLERGEN V5/TPX-1-RELATED FAMILY PROTEIN
AT5G57625

Predicted

Affinity Capture-MS

Affinity Capture-MS

FSW = 0.0171

Unknown

 ALLERGEN V5/TPX-1-RELATED FAMILY PROTEIN
AT1G01020

Predicted

Co-purification

FSW = 0.0240

Unknown

 ARV1
AT1G16470

Predicted

two hybrid

FSW = 0.0076

Unknown

 PAB1 (PROTEASOME SUBUNIT PAB1) ENDOPEPTIDASE/ PEPTIDASE/ THREONINE-TYPE ENDOPEPTIDASE
AT3G25980

Predicted

two hybrid

FSW = 0.0044

Unknown

 MITOTIC SPINDLE CHECKPOINT PROTEIN PUTATIVE (MAD2)
AT5G28060

Predicted

Phenotypic Enhancement

FSW = 0.0202

Unknown

 40S RIBOSOMAL PROTEIN S24 (RPS24B)
AT5G53360

Predicted

two hybrid

FSW = 0.0126

Unknown

 SEVEN IN ABSENTIA (SINA) FAMILY PROTEIN
AT4G17190

Predicted

Affinity Capture-MS

FSW = 0.0079

Unknown

 FPS2 (FARNESYL DIPHOSPHATE SYNTHASE 2) DIMETHYLALLYLTRANSTRANSFERASE/ GERANYLTRANSTRANSFERASE
AT3G27530

Predicted

two hybrid

FSW = 0.0185

Unknown

 GC6 (GOLGIN CANDIDATE 6) BINDING / PROTEIN TRANSPORTER
AT4G28470

Predicted

two hybrid

FSW = 0.0137

Unknown

 RPN1B (26S PROTEASOME REGULATORY SUBUNIT S2 1B) BINDING / ENZYME REGULATOR
AT2G16950

Predicted

two hybrid

FSW = 0.0039

Unknown

 TRN1 (TRANSPORTIN 1) PROTEIN TRANSPORTER
AT3G07370

Predicted

two hybrid

FSW = 0.0137

Unknown

 CHIP (CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN) UBIQUITIN-PROTEIN LIGASE
AT3G24080

Predicted

two hybrid

FSW = 0.0029

Unknown

 KRR1 FAMILY PROTEIN
AT4G11330

Predicted

two hybrid

FSW = 0.0143

Unknown

 ATMPK5 (MAP KINASE 5) MAP KINASE/ KINASE
AT4G14305

Predicted

two hybrid

FSW = 0.0278

Unknown

 FUNCTIONS IN MOLECULAR_FUNCTION UNKNOWN INVOLVED IN BIOLOGICAL_PROCESS UNKNOWN LOCATED IN INTEGRAL TO MEMBRANE CONTAINS INTERPRO DOMAIN/S MPV17/PMP22 (INTERPROIPR007248) BEST ARABIDOPSIS THALIANA PROTEIN MATCH IS PMP22 (TAIRAT4G044701) HAS 957 BLAST HITS TO 957 PROTEINS IN 126 SPECIES ARCHAE - 0 BACTERIA - 0 METAZOA - 456 FUNGI - 286 PLANTS - 164 VIRUSES - 0 OTHER EUKARYOTES - 51 (SOURCE NCBI BLINK)
AT4G36630

Predicted

two hybrid

FSW = 0.0388

Unknown

 EMB2754 (EMBRYO DEFECTIVE 2754) BINDING / SMALL GTPASE REGULATOR
AT2G39240

Predicted

two hybrid

FSW = 0.0139

Unknown

 RNA POLYMERASE I TRANSCRIPTION FACTOR/ BINDING
AT3G27180

Predicted

two hybrid

FSW = 0.0278

Unknown

 UNKNOWN PROTEIN
AT3G46220

Predicted

two hybrid

FSW = 0.0137

Unknown

 UNKNOWN PROTEIN
AT5G09880

Predicted

two hybrid

FSW = 0.0069

Unknown

 RNA RECOGNITION MOTIF (RRM)-CONTAINING PROTEIN
AT5G42400

Predicted

Phenotypic Suppression

Phenotypic Enhancement

FSW = 0.0161

Unknown

 SDG25 (SET DOMAIN PROTEIN 25)
AT5G54590

Predicted

two hybrid

FSW = 0.0110

Unknown

 PROTEIN KINASE FAMILY PROTEIN
AT5G01390

Predicted

Affinity Capture-MS

FSW = 0.0347

Unknown

 DNAJ HEAT SHOCK PROTEIN PUTATIVE
AT5G02150

Predicted

in vitro

two hybrid

Affinity Capture-MS

FSW = 0.0435

Unknown

 BINDING
AT2G32850

Predicted

in vivo

in vitro

Affinity Capture-MS

FSW = 0.0229

Unknown

 PROTEIN KINASE FAMILY PROTEIN
AT2G36360

Predicted

Affinity Capture-MS

FSW = 0.0594

Unknown

 KELCH REPEAT-CONTAINING PROTEIN
AT5G26360

Predicted

in vivo

Affinity Capture-MS

FSW = 0.0082

Unknown

 CHAPERONIN PUTATIVE
AT1G02630

Predicted

Affinity Capture-MS

co-fractionation

Co-fractionation

Affinity Capture-MS

Affinity Capture-MS

Affinity Capture-MS

Affinity Capture-MS

Affinity Capture-Western

co-fractionation

Co-fractionation

FSW = 0.0439

Unknown

 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER PUTATIVE (ENT8)
AT1G06090

Predicted

two hybrid

interologs mapping

FSW = 0.0337

Unknown

 FATTY ACID DESATURASE FAMILY PROTEIN
AT2G19910

Predicted

Affinity Capture-MS

FSW = 0.0123

Unknown

 RNA-DEPENDENT RNA POLYMERASE FAMILY PROTEIN
AT2G20290

Predicted

Affinity Capture-MS

FSW = 0.0164

Unknown

 XIG MOTOR/ PROTEIN BINDING
AT2G27170

Predicted

Affinity Capture-MS

FSW = 0.0187

Unknown

 TTN7 (TITAN7) ATP BINDING / PROTEIN BINDING
AT2G35390

Predicted

Affinity Capture-MS

FSW = 0.0265

Unknown

 RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1 / PHOSPHORIBOSYL DIPHOSPHATE SYNTHETASE 1 (PRSI)
AT2G47090

Predicted

interologs mapping

FSW = 0.0321

Unknown

 NUCLEIC ACID BINDING / PROTEIN BINDING / ZINC ION BINDING
AT3G04710

Predicted

Synthetic Lethality

FSW = 0.0131

Unknown

 ANKYRIN REPEAT FAMILY PROTEIN
AT3G12200

Predicted

Affinity Capture-MS

FSW = 0.0168

Unknown

 ATNEK7 (NIMA-RELATED KINASE7) ATP BINDING / KINASE/ PROTEIN KINASE/ PROTEIN SERINE/THREONINE KINASE/ PROTEIN TYROSINE KINASE
AT3G14370

Predicted

Phenotypic Suppression

FSW = 0.0128

Unknown

 WAG2 KINASE/ PROTEIN SERINE/THREONINE KINASE
AT3G14390

Predicted

Affinity Capture-MS

FSW = 0.0169

Unknown

 DIAMINOPIMELATE DECARBOXYLASE PUTATIVE / DAP CARBOXYLASE PUTATIVE
AT3G17520

Predicted

Affinity Capture-MS

Affinity Capture-MS

Affinity Capture-MS

Affinity Capture-MS

FSW = 0.0962

Unknown

 LATE EMBRYOGENESIS ABUNDANT DOMAIN-CONTAINING PROTEIN / LEA DOMAIN-CONTAINING PROTEIN
AT3G19670Predicted

Affinity Capture-MS

FSW = 0.0084

Unknown

 PROTEIN BINDING
AT4G21800

Predicted

Affinity Capture-MS

FSW = 0.0335

Unknown

 QQT2 (QUATRE-QUART2) ATP BINDING / NUCLEOTIDE BINDING
AT1G11510

Predicted

synthetic growth defect

FSW = 0.0086

Unknown

 DNA-BINDING STOREKEEPER PROTEIN-RELATED
AT1G49520

Predicted

Co-purification

FSW = 0.0346

Unknown

 SWIB COMPLEX BAF60B DOMAIN-CONTAINING PROTEIN
AT1G71530

Predicted

two hybrid

FSW = 0.0474

Unknown

 PROTEIN KINASE FAMILY PROTEIN
AT2G46650

Predicted

two hybrid

FSW = 0.0351

Unknown

 CB5-C (CYTOCHROME B5 ISOFORM C) HEME BINDING
AT3G05040

Predicted

two hybrid

FSW = 0.0809

Unknown

 HST (HASTY) NUCLEOCYTOPLASMIC TRANSPORTER
AT3G18860

Predicted

two hybrid

FSW = 0.0105

Unknown

 TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN
AT3G61210

Predicted

two hybrid

FSW = 0.0211

Unknown

 EMBRYO-ABUNDANT PROTEIN-RELATED
AT5G19090

Predicted

two hybrid

FSW = 0.0246

Unknown

 HEAVY-METAL-ASSOCIATED DOMAIN-CONTAINING PROTEIN
AT3G14730

Predicted

Gene fusion method

FSW = 0.0108

Unknown

 PENTATRICOPEPTIDE (PPR) REPEAT-CONTAINING PROTEIN

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Quick help

Experimental: This means that the indicated PPI was experimentally demonstrated using Arabidopsis thaliana proteins as model of study. The experiment indicated links to the publication of which this interaction was annotated from
Predicted: The indicated PPI was proposed based on ortholgs studies. The experiment indicated links to the publication of the orthologous PPI was annotated from

FSW

FSW is the Functional Similarity Weight. It represents the proportion of interaction partners that two proteins have in common

Learn more - FSWeight top ranked cut offs

C3

Class A: The PPI is a direct evidence (experimental), the subcellular location was experimentally demonstrated and both, target and source, were indicated as expressed in same cellular compartment
Class B: The PPI is a direct evidence (experimental), the subcellular location was experimentally demonstrated but both, target and source, were indicated as expressed in different cellular compartment
Class C: Same as Class A but the PPI is predicted
Class D: Same as Class A but subcellular location was predicted. P(exp|pred) indicates the probability of this particular predicted location be experimentally demonstrated given all data available on AtPINDB
Unknown: There is no available data to calculate the C3 or the data does not fit onto any class previously described

PEP

PEP is the posterior probability of this particular PPI be experimentally demonstrated once it was predicted. For this release p = 0.0030. If they share same cell compartment p = 0.0029

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How to cite

If you find AtPIN interesting and want to use it in your work please cite us

AtPIN: Arabidopsis thaliana Protein Interaction Network
Marcelo M Brandao, Luiza L Dantas and Marcio C Silva-Filho
BMC Bioinformatics 2009, 10:454

DOI:1471-2105/10/454

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