Arabidopsis thaliana protein interaction network
Laboratório de Biologia Integrativa e Sistêmica (LaBIS)
Laboratório de Biologia Integrativa e Sistêmica (LaBIS)
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AT5G38470 - ( DNA repair protein RAD23 putative )
91 Proteins interacs with AT5G38470Locus | Method | FSW | Cellular Compartment Classification (C3) | Description |
---|---|---|---|---|
AT2G01720 | PredictedAffinity Capture-MSin vivoin vitro | FSW = 0.0059
| Unknown | RIBOPHORIN I FAMILY PROTEIN |
AT4G14800 | PredictedAffinity Capture-Western | FSW = 0.1306
| Unknown | PBD2 (20S PROTEASOME BETA SUBUNIT 2) PEPTIDASE/ THREONINE-TYPE ENDOPEPTIDASE |
AT1G18070 | PredictedAffinity Capture-MS | FSW = 0.0374
| Unknown | EF-1-ALPHA-RELATED GTP-BINDING PROTEIN PUTATIVE |
AT5G55400 | PredictedAffinity Capture-MS | FSW = 0.0397
| Unknown | FIMBRIN-LIKE PROTEIN PUTATIVE |
AT1G30480 | Predictedtwo hybrid | FSW = 0.0426
| Unknown | DRT111 NUCLEIC ACID BINDING / NUCLEOTIDE BINDING |
AT1G16030 | PredictedAffinity Capture-MS | FSW = 0.0034
| Unknown | HSP70B (HEAT SHOCK PROTEIN 70B) ATP BINDING |
AT5G16630 | Predictedtwo hybridin vivotwo hybridAffinity Capture-Westerntwo hybridAffinity Capture-WesternAffinity Capture-Westerntwo hybridAffinity Capture-MSAffinity Capture-MSAffinity Capture-Westerntwo hybridin vivoAffinity Capture-MSCo-purificationPhenotypic Suppression | FSW = 0.0770
| Unknown | RAD4 DAMAGED DNA BINDING |
AT5G63110 | PredictedPhenotypic Enhancement | FSW = 0.0223
| Unknown | HDA6 (HISTONE DEACETYLASE 6) HISTONE DEACETYLASE |
AT4G35800 | PredictedAffinity Capture-Western | FSW = 0.0353
| Unknown | NRPB1 (RNA POLYMERASE II LARGE SUBUNIT) DNA BINDING / DNA-DIRECTED RNA POLYMERASE |
AT5G60390 | Predictedinterologs mapping | FSW = 0.0320
| Unknown | ELONGATION FACTOR 1-ALPHA / EF-1-ALPHA |
AT2G20580 | PredictedReconstituted Complextwo hybridtwo hybridAffinity Capture-MSAffinity Capture-WesternReconstituted Complex | FSW = 0.1107
| Unknown | RPN1A (26S PROTEASOME REGULATORY SUBUNIT S2 1A) BINDING / ENZYME REGULATOR |
AT1G53750 | PredictedAffinity Capture-WesternAffinity Capture-WesternAffinity Capture-Westerntwo hybridAffinity Capture-WesternCo-purificationAffinity Capture-MS | FSW = 0.1614
| Unknown | RPT1A (REGULATORY PARTICLE TRIPLE-A 1A) ATPASE |
AT3G43810 | PredictedAffinity Capture-MS | FSW = 0.0066
| Unknown | CAM7 (CALMODULIN 7) CALCIUM ION BINDING |
AT5G19990 | PredictedAffinity Capture-WesternAffinity Capture-WesternAffinity Capture-WesternAffinity Capture-MSAffinity Capture-WesternCo-purificationPhenotypic Enhancement | FSW = 0.1183
| Unknown | RPT6A (REGULATORY PARTICLE TRIPLE-A ATPASE 6A) ATPASE |
AT1G75990 | PredictedAffinity Capture-MS | FSW = 0.1659
| Unknown | 26S PROTEASOME REGULATORY SUBUNIT S3 PUTATIVE (RPN3) |
AT3G04470 | Predictedtwo hybrid | FSW = 0.0340
| Unknown | FUNCTIONS IN MOLECULAR_FUNCTION UNKNOWN INVOLVED IN BIOLOGICAL_PROCESS UNKNOWN LOCATED IN PLASMA MEMBRANE EXPRESSED IN 25 PLANT STRUCTURES EXPRESSED DURING 15 GROWTH STAGES CONTAINS INTERPRO DOMAIN/S ANKYRIN (INTERPROIPR002110) BEST ARABIDOPSIS THALIANA PROTEIN MATCH IS ANKYRIN REPEAT FAMILY PROTEIN (TAIRAT1G047801) HAS 842 BLAST HITS TO 642 PROTEINS IN 95 SPECIES ARCHAE - 0 BACTERIA - 6 METAZOA - 523 FUNGI - 26 PLANTS - 165 VIRUSES - 4 OTHER EUKARYOTES - 118 (SOURCE NCBI BLINK) |
AT3G17750 | Predictedtwo hybrid | FSW = 0.0222
| Unknown | PROTEIN KINASE FAMILY PROTEIN |
AT4G37010 | Predictedin vivoin vitroAffinity Capture-MS | FSW = 0.0136
| Unknown | CALTRACTIN PUTATIVE / CENTRIN PUTATIVE |
AT5G41370 | PredictedReconstituted Complex | FSW = 0.0148
| Unknown | XPB1 (ARABIDOPSIS HOMOLOG OF XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP B 1) ATP BINDING / ATP-DEPENDENT DNA HELICASE/ ATP-DEPENDENT HELICASE/ DNA BINDING / HELICASE/ HYDROLASE/ NUCLEIC ACID BINDING |
AT3G05530 | PredictedAffinity Capture-WesternCo-purificationAffinity Capture-MS | FSW = 0.2132
| Unknown | RPT5A (REGULATORY PARTICLE TRIPLE-A ATPASE 5A) ATPASE/ CALMODULIN BINDING |
AT4G17020 | PredictedAffinity Capture-Western | FSW = 0.0420
| Unknown | TRANSCRIPTION FACTOR-RELATED |
AT3G55930 | Predictedtwo hybrid | FSW = 0.0077
| Unknown | RNA SPLICING FACTOR-RELATED |
AT4G20440 | Predictedtwo hybrid | FSW = 0.0095
| Unknown | SMB (SMALL NUCLEAR RIBONUCLEOPROTEIN ASSOCIATED PROTEIN B) |
AT5G44500 | Predictedtwo hybrid | FSW = 0.0079
| Unknown | SMALL NUCLEAR RIBONUCLEOPROTEIN ASSOCIATED PROTEIN B PUTATIVE / SNRNP-B PUTATIVE / SM PROTEIN B PUTATIVE |
AT4G10710 | PredictedAffinity Capture-Western | FSW = 0.0396
| Unknown | SPT16 (GLOBAL TRANSCRIPTION FACTOR C) |
AT2G36170 | Predictedtwo hybridAffinity Capture-MS | FSW = 0.0067
| Unknown | UBIQUITIN EXTENSION PROTEIN 2 (UBQ2) / 60S RIBOSOMAL PROTEIN L40 (RPL40A) |
AT1G05120 | PredictedPhenotypic Enhancement | FSW = 0.0133
| Unknown | SNF2 DOMAIN-CONTAINING PROTEIN / HELICASE DOMAIN-CONTAINING PROTEIN / RING FINGER DOMAIN-CONTAINING PROTEIN |
AT1G55750 | PredictedReconstituted Complex | FSW = 0.0172
| Unknown | TRANSCRIPTION FACTOR-RELATED |
AT2G24490 | PredictedPhenotypic Enhancement | FSW = 0.0315
| Unknown | RPA2 (REPLICON PROTEIN A2) PROTEIN BINDING |
AT5G14170 | Predictedtwo hybrid | FSW = 0.0058
| Unknown | CHC1 |
AT3G13445 | PredictedAffinity Capture-Western | FSW = 0.0362
| Unknown | TBP1 (TATA BINDING PROTEIN 1) DNA BINDING / RNA POLYMERASE II TRANSCRIPTION FACTOR/ BINDING |
AT1G28060 | Predictedtwo hybrid | FSW = 0.0062
| Unknown | SMALL NUCLEAR RIBONUCLEOPROTEIN FAMILY PROTEIN / SNRNP FAMILY PROTEIN |
AT1G07370 | PredictedPhenotypic Enhancement | FSW = 0.0460
| Unknown | PCNA1 (PROLIFERATING CELLULAR NUCLEAR ANTIGEN) DNA BINDING / DNA POLYMERASE PROCESSIVITY FACTOR/ PROTEIN BINDING |
AT2G18760 | PredictedPhenotypic Enhancement | FSW = 0.0264
| Unknown | CHR8 (CHROMATIN REMODELING 8) ATP BINDING / DNA BINDING / HELICASE/ NUCLEIC ACID BINDING |
AT2G47770 | Predictedtwo hybrid | FSW = 0.0170
| Unknown | BENZODIAZEPINE RECEPTOR-RELATED |
AT5G02730 | Predictedtwo hybrid | FSW = 0.0112
| Unknown | ALLERGEN V5/TPX-1-RELATED FAMILY PROTEIN |
AT1G76400 | PredictedAffinity Capture-MSin vitroin vivo | FSW = 0.0032
| Unknown | RIBOPHORIN I FAMILY PROTEIN |
AT2G31200 | PredictedAffinity Capture-MS | FSW = 0.0148
| Unknown | ADF6 (ACTIN DEPOLYMERIZING FACTOR 6) ACTIN BINDING |
AT3G25980 | PredictedSynthetic Lethality | FSW = 0.0303
| Unknown | MITOTIC SPINDLE CHECKPOINT PROTEIN PUTATIVE (MAD2) |
AT2G31300 | PredictedAffinity Capture-MS | FSW = 0.0295
| Unknown | ARPC1B (ACTIN-RELATED PROTEIN C1B) ACTIN BINDING / NUCLEOTIDE BINDING |
AT3G54130 | Predictedin vivoAffinity Capture-MS | FSW = 0.0632
| Unknown | JOSEPHIN FAMILY PROTEIN |
AT5G03340 | PredictedAffinity Capture-Western | FSW = 0.0713
| Unknown | CELL DIVISION CYCLE PROTEIN 48 PUTATIVE / CDC48 PUTATIVE |
AT5G58290 | PredictedAffinity Capture-MSAffinity Capture-MSAffinity Capture-Western | FSW = 0.1897
| Unknown | RPT3 (REGULATORY PARTICLE TRIPLE-A ATPASE 3) ATPASE |
AT5G20850 | PredictedAffinity Capture-MS | FSW = 0.0602
| Unknown | ATRAD51 ATP BINDING / DNA BINDING / DNA-DEPENDENT ATPASE/ DAMAGED DNA BINDING / NUCLEOSIDE-TRIPHOSPHATASE/ NUCLEOTIDE BINDING / PROTEIN BINDING / SEQUENCE-SPECIFIC DNA BINDING |
AT1G79650 | PredictedPhylogenetic profile methodCo-expression | FSW = 0.1001
| Unknown | RAD23 DAMAGED DNA BINDING |
AT3G12040 | PredictedAffinity Capture-MS | FSW = 0.0213
| Unknown | DNA-3-METHYLADENINE GLYCOSYLASE (MAG) |
AT3G13235 | PredictedPhenotypic Enhancementtwo hybridtwo hybridtwo hybridAffinity Capture-Westernco-fractionationCo-fractionationReconstituted ComplexPhenotypic Enhancement | FSW = 0.0543
| Unknown | UBIQUITIN FAMILY PROTEIN |
AT4G38630 | Predictedtwo hybridtwo hybridin vivoin vivoin vitroin vitroAffinity Capture-MSPhenotypic Enhancementsynthetic growth defectPhenotypic EnhancementPhenotypic EnhancementAffinity Capture-MStwo hybridAffinity Capture-MSSynthetic Lethalitysynthetic growth defectAffinity Capture-WesternPhenotypic Enhancementin vitroin vivoCo-expression | FSW = 0.1769
| Unknown | RPN10 (REGULATORY PARTICLE NON-ATPASE 10) PEPTIDE RECEPTOR |
AT1G53780 | Predictedtwo hybrid | FSW = 0.1120
| Unknown | ATP BINDING / ATPASE/ HYDROLASE/ NUCLEOSIDE-TRIPHOSPHATASE/ NUCLEOTIDE BINDING / PEPTIDYL-PROLYL CIS-TRANS ISOMERASE |
AT2G47110 | Predictedtwo hybrid | FSW = 0.0420
| Unknown | UBQ6 PROTEIN BINDING |
AT3G52590 | Predictedtwo hybrid | FSW = 0.0131
| Unknown | UBQ1 (UBIQUITIN EXTENSION PROTEIN 1) PROTEIN BINDING / STRUCTURAL CONSTITUENT OF RIBOSOME |
AT1G71980 | Predictedtwo hybrid | FSW = 0.0426
| Unknown | PROTEASE-ASSOCIATED ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN |
AT2G47350 | Predictedtwo hybrid | FSW = 0.0100
| Unknown | PAPA-1-LIKE FAMILY PROTEIN / ZINC FINGER (HIT TYPE) FAMILY PROTEIN |
AT4G20325 | Predictedtwo hybrid | FSW = 0.0095
| Unknown | UNKNOWN PROTEIN |
AT5G16870 | PredictedAffinity Capture-Westerntwo hybrid | FSW = 0.0588
| Unknown | AMINOACYL-TRNA HYDROLASE |
AT5G47240 | Predictedtwo hybrid | FSW = 0.0190
| Unknown | ATNUDT8 (ARABIDOPSIS THALIANA NUDIX HYDROLASE HOMOLOG 8) HYDROLASE |
AT5G47650 | Predictedtwo hybrid | FSW = 0.0108
| Unknown | ATNUDT2 (ARABIDOPSIS THALIANA NUDIX HYDROLASE HOMOLOG 2) ADP-RIBOSE DIPHOSPHATASE/ NAD OR NADH BINDING / HYDROLASE |
AT5G52545 | Predictedtwo hybrid | FSW = 0.0104
| Unknown | UNKNOWN PROTEIN |
AT5G49570 | Predictedtwo hybridAffinity Capture-Westerntwo hybridAffinity Capture-Westerntwo hybridCo-crystal StructureReconstituted ComplexAffinity Capture-MS | FSW = 0.0226
| Unknown | ATPNG1 (ARABIDOPSIS THALIANA PEPTIDE-N-GLYCANASE 1) CATALYTIC/ PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE |
AT5G54590 | Predictedtwo hybrid | FSW = 0.0233
| Unknown | PROTEIN KINASE FAMILY PROTEIN |
AT5G63550 | Predictedtwo hybrid | FSW = 0.0222
| Unknown | EXPRESSED IN GUARD CELL CULTURED CELL CONTAINS INTERPRO DOMAIN/S DEK C-TERMINAL (INTERPROIPR014876) BEST ARABIDOPSIS THALIANA PROTEIN MATCH IS UNKNOWN PROTEIN (TAIRAT3G487101) HAS 115795 BLAST HITS TO 50006 PROTEINS IN 1760 SPECIES ARCHAE - 230 BACTERIA - 10317 METAZOA - 57515 FUNGI - 12631 PLANTS - 4292 VIRUSES - 1075 OTHER EUKARYOTES - 29735 (SOURCE NCBI BLINK) |
AT1G13180 | PredictedAffinity Capture-MS | FSW = 0.0319
| Unknown | DIS1 (DISTORTED TRICHOMES 1) ATP BINDING / ACTIN BINDING / PROTEIN BINDING / STRUCTURAL CONSTITUENT OF CYTOSKELETON |
AT1G29150 | PredictedAffinity Capture-MS | FSW = 0.1346
| Unknown | ATS9 (ARABIDOPSIS NON-ATPASE SUBUNIT 9) |
AT1G64520 | PredictedAffinity Capture-MS | FSW = 0.1606
| Unknown | RPN12A (REGULATORY PARTICLE NON-ATPASE 12A) PEPTIDASE |
AT2G02760 | PredictedPhenotypic EnhancementPhenotypic Enhancementsynthetic growth defect | FSW = 0.0908
| Unknown | ATUBC2 (UBIQUITING-CONJUGATING ENZYME 2) UBIQUITIN-PROTEIN LIGASE |
AT2G17190 | Predictedsynthetic growth defectPhenotypic Enhancementsynthetic growth defectPhenotypic Enhancementtwo hybridPhenotypic Enhancementsynthetic growth defect | FSW = 0.1479
| Unknown | UBIQUITIN FAMILY PROTEIN |
AT2G32730 | PredictedAffinity Capture-MS | FSW = 0.1683
| Unknown | 26S PROTEASOME REGULATORY SUBUNIT PUTATIVE |
AT3G11270 | PredictedAffinity Capture-MS | FSW = 0.1530
| Unknown | MEE34 (MATERNAL EFFECT EMBRYO ARREST 34) |
AT3G27000 | PredictedAffinity Capture-MS | FSW = 0.0277
| Unknown | ARP2 (ACTIN RELATED PROTEIN 2) PROTEIN BINDING / STRUCTURAL CONSTITUENT OF CYTOSKELETON |
AT4G05320 | Predictedtwo hybridCo-crystal StructureAffinity Capture-WesternReconstituted Complex | FSW = 0.0583
| Unknown | UBQ10 (POLYUBIQUITIN 10) PROTEIN BINDING |
AT4G19006 | PredictedAffinity Capture-MSAffinity Capture-MSAffinity Capture-Western | FSW = 0.1782
| Unknown | 26S PROTEASOME REGULATORY SUBUNIT PUTATIVE (RPN9) |
AT4G29040 | PredictedAffinity Capture-MSAffinity Capture-MS | FSW = 0.2402
| Unknown | RPT2A (REGULATORY PARTICLE AAA-ATPASE 2A) ATPASE |
AT5G15400 | Predictedtwo hybridAffinity Capture-MSAffinity Capture-WesternAffinity Capture-WesternSynthetic RescueAffinity Capture-MStwo hybridReconstituted ComplexCo-purification | FSW = 0.1153
| Unknown | U-BOX DOMAIN-CONTAINING PROTEIN |
AT5G23540 | PredictedAffinity Capture-MS | FSW = 0.1510
| Unknown | 26S PROTEASOME REGULATORY SUBUNIT PUTATIVE |
AT1G04020 | Predictedsynthetic growth defect | FSW = 0.0804
| Unknown | BARD1 (BREAST CANCER ASSOCIATED RING 1) DNA BINDING / TRANSCRIPTION COACTIVATOR |
AT1G04730 | PredictedSynthetic Lethality | FSW = 0.0522
| Unknown | AAA-TYPE ATPASE FAMILY PROTEIN |
AT1G32130 | PredictedPhenotypic Enhancement | FSW = 0.0191
| Unknown | FUNCTIONS IN MOLECULAR_FUNCTION UNKNOWN INVOLVED IN BIOLOGICAL_PROCESS UNKNOWN LOCATED IN CELLULAR_COMPONENT UNKNOWN EXPRESSED IN 25 PLANT STRUCTURES EXPRESSED DURING 15 GROWTH STAGES CONTAINS INTERPRO DOMAIN/S TFIIS N-TERMINAL (INTERPROIPR017923) IWS1 C-TERMINAL (INTERPROIPR008654) BEST ARABIDOPSIS THALIANA PROTEIN MATCH IS IWS1 C-TERMINUS FAMILY PROTEIN (TAIRAT4G190001) HAS 907 BLAST HITS TO 871 PROTEINS IN 182 SPECIES ARCHAE - 4 BACTERIA - 14 METAZOA - 417 FUNGI - 195 PLANTS - 42 VIRUSES - 8 OTHER EUKARYOTES - 227 (SOURCE NCBI BLINK) |
AT1G59890 | PredictedPhenotypic Enhancement | FSW = 0.0284
| Unknown | SNL5 (SIN3-LIKE 5) |
AT1G64550 | PredictedPhenotypic Enhancement | FSW = 0.0133
| Unknown | ATGCN3 TRANSPORTER |
AT1G78870 | PredictedPhenotypic Enhancement | FSW = 0.0123
| Unknown | UBC35 (UBIQUITIN-CONJUGATING ENZYME 35) PROTEIN BINDING / UBIQUITIN-PROTEIN LIGASE |
AT2G06040 | PredictedAffinity Capture-Western | FSW = 0.0800
| Unknown | FUNCTIONS IN MOLECULAR_FUNCTION UNKNOWN INVOLVED IN BIOLOGICAL_PROCESS UNKNOWN LOCATED IN CELLULAR_COMPONENT UNKNOWN EXPRESSED IN 17 PLANT STRUCTURES EXPRESSED DURING 10 GROWTH STAGES CONTAINS INTERPRO DOMAIN/S LEUCINE-RICH REPEAT CYSTEINE-CONTAINING SUBTYPE (INTERPROIPR006553) BEST ARABIDOPSIS THALIANA PROTEIN MATCH IS UNKNOWN PROTEIN (TAIRAT5G219001) HAS 3642 BLAST HITS TO 1885 PROTEINS IN 175 SPECIES ARCHAE - 0 BACTERIA - 109 METAZOA - 2066 FUNGI - 492 PLANTS - 697 VIRUSES - 0 OTHER EUKARYOTES - 278 (SOURCE NCBI BLINK) |
AT2G15910 | PredictedAffinity Capture-MS | FSW = 0.0145
| Unknown | CSL ZINC FINGER DOMAIN-CONTAINING PROTEIN |
AT2G44580 | PredictedSynthetic Lethality | FSW = 0.0623
| Unknown | PROTEIN BINDING / ZINC ION BINDING |
AT3G02820 | PredictedPhenotypic Enhancement | FSW = 0.0894
| Unknown | ZINC KNUCKLE (CCHC-TYPE) FAMILY PROTEIN |
AT3G42660 | PredictedSynthetic Lethality | FSW = 0.0612
| Unknown | NUCLEOTIDE BINDING |
AT3G57870 | PredictedPhenotypic Enhancement | FSW = 0.0251
| Unknown | SCE1 (SUMO CONJUGATION ENZYME 1) SUMO LIGASE |
AT5G26680 | Predictedsynthetic growth defect | FSW = 0.0313
| Unknown | ENDONUCLEASE PUTATIVE |
AT5G43010 | PredictedPhenotypic EnhancementAffinity Capture-WesternCo-purificationAffinity Capture-MS | FSW = 0.2262
| Unknown | RPT4A ATPASE |
AT5G46030 | PredictedPhenotypic Enhancement | FSW = 0.0086
| Unknown | UNKNOWN PROTEIN |
AT5G40580 | PredictedAffinity Capture-Western | FSW = 0.0135
| Unknown | PBB2 ENDOPEPTIDASE/ PEPTIDASE/ THREONINE-TYPE ENDOPEPTIDASE |
AT5G41700 | PredictedSynthetic RescuePhenotypic Suppression | FSW = 0.0432
| Unknown | UBC8 (UBIQUITIN CONJUGATING ENZYME 8) PROTEIN BINDING / UBIQUITIN-PROTEIN LIGASE |
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Experimental: This means that the indicated PPI was experimentally demonstrated using Arabidopsis thaliana proteins as model of study. The experiment indicated links to the publication of which this interaction was annotated from
Predicted: The indicated PPI was proposed based on ortholgs studies. The experiment indicated links to the publication of the orthologous PPI was annotated from
FSW
FSW is the Functional Similarity Weight. It represents the proportion of interaction partners that two proteins have in commonLearn more - FSWeight top ranked cut offs
C3
Class A: The PPI is a direct evidence (experimental), the subcellular location was experimentally demonstrated and both, target and source, were indicated as expressed in same cellular compartment
Class B: The PPI is a direct evidence (experimental), the subcellular location was experimentally demonstrated but both, target and source, were indicated as expressed in different cellular compartment
Class C: Same as Class A but the PPI is predicted
Class D: Same as Class A but subcellular location was predicted. P(exp|pred) indicates the probability of this particular predicted location be experimentally demonstrated given all data available on AtPINDB
Unknown: There is no available data to calculate the C3 or the data does not fit onto any class previously described
PEP
PEP is the posterior probability of this particular PPI be experimentally demonstrated once it was predicted. For this release p = 0.0030. If they share same cell compartment p = 0.0029Learn more
How to cite
If you find AtPIN interesting and want to use it in your work please cite usAtPIN: Arabidopsis thaliana Protein Interaction Network
Marcelo M Brandao, Luiza L Dantas and Marcio C Silva-Filho
BMC Bioinformatics 2009, 10:454DOI:1471-2105/10/454
Marcelo M Brandao, Luiza L Dantas and Marcio C Silva-Filho
BMC Bioinformatics 2009, 10:454DOI:1471-2105/10/454